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目的制备一种定向药物载体,该载体属于靶向给药系统的一种新的剂型。方法熔融法。将大豆磷脂和表面活性剂加少量水相溶解,胆固醇熔融后,在65℃左右的水相溶液中保温制得。结果制备5个批号多相脂质体注射液,放置2年时间包封率没有明显改变。结论用本工艺制备油酸多相脂质体,方法简便、实用、不使用有机溶剂,适用于工业化生产。
Objective To prepare a targeted drug carrier that belongs to a new dosage form for targeted drug delivery systems. Method of melting method. The soybean phospholipid and surfactant plus a small amount of water dissolved, cholesterol melted at about 65 ℃ aqueous solution in the insulation system. Results Preparation of 5 batches of multiphase liposome injection, placed 2 years encapsulation efficiency did not change significantly. Conclusion The preparation of oleic acid multiphase liposomes by this process is simple, practical and does not use organic solvents, suitable for industrial production.