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目的:原卟啉二钠片预防抗精神病药致肝功能异常的疗效。方法:将精神分裂症患者随机分为预防组(第1组、第2组和第3组)和空白组(第4组),预防组分别在不同时间给予原卟啉二钠片,而空白对照组未服用任何保肝药,观察临床症状及ALT、AST的变化。结果:预防组的肝功能指标与空白对照组比较有统计学意义(P<0.001)。结论:原卟啉二钠片具有明显的预防抗精神病药致肝功能异常的疗效。
OBJECTIVE: To observe the curative effect of protoporphyrin disodium on prevention of liver dysfunction caused by antipsychotics. Methods: Patients with schizophrenia were randomly divided into prophylaxis group (group 1, group 2 and group 3) and blank group (group 4). The prophylaxis group was given protoporphyrin disodium tablets at different times, while the blank The control group did not take any hepatoprotective drugs to observe the clinical symptoms and ALT, AST changes. Results: The indexes of liver function in the prevention group were statistically significant compared with the control group (P <0.001). Conclusion: Protoporphyrin disodium tablets have the obvious effect of preventing the abnormal liver function induced by antipsychotics.