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[目的]探讨联合奥曲肽与单用奥美拉唑治疗非曲张静脉出血所致上消化道出血的疗效及对BUN/Cr比值的影响。[方法]选择诊断为非曲张静脉出血所致上消化道出血患者100例,按照入院顺序随机分为观察组和对照组,各50例,分别予奥美拉唑联合奥曲肽(奥美拉唑40mg,奥曲肽0.1mg静脉推注后,另取0.32mg静脉泵入)与单纯奥美拉唑治疗,2次/d,3d为一疗程;记录并比较2组患者治疗前后BUN/Cr比值、临床总有效率、止血时间、输血量及再出血率,并对比2组药物不良反应情况。[结果]2组经治疗后BUN/Cr比值均有下降,但观察组下降幅度更明显,相比对照组差异有统计学意义(P<0.05);观察组有效率(92%)显著高于对照组(70%),差异有统计学意义(χ2=7.862,P<0.05);观察组在止血时间、输血量上显著优于对照组(P<0.05)。[结论]奥美拉唑联合奥曲肽治疗非曲张静脉出血所致上消化道出血可明显降低BUN/Cr比值,止血效果良好,作用稳定持久,无明显药物不良反应,值得临床上推广应用。
[Objective] To investigate the curative effect of combination of octreotide and omeprazole on upper gastrointestinal hemorrhage caused by non-variceal bleeding and its effect on BUN / Cr ratio. [Methods] One hundred patients with upper gastrointestinal hemorrhage who were diagnosed as non-variceal bleeding were randomly divided into observation group and control group according to the order of admission, and 50 patients in each group were given omeprazole combined with octreotide (omeprazole 40mg , Octreotide 0.1mg intravenous injection, another 0.32mg intravenous infusion) and simple omeprazole treatment, 2 times / d, 3d for a course of treatment; record and compare the two groups of patients before and after treatment BUN / Cr ratio, total clinical Efficacy, bleeding time, blood transfusion and rebleeding rate, and compared two groups of adverse drug reactions. [Results] The BUN / Cr ratio decreased in both groups after treatment, but the decrease rate in observation group was more obvious than that in control group (P <0.05). The effective rate (92%) in observation group was significantly higher than that in control group The control group (70%), the difference was statistically significant (χ2 = 7.862, P <0.05); the observation group was significantly better than the control group in bleeding time and blood transfusion (P <0.05). [Conclusion] Omeprazole combined with octreotide in treatment of upper gastrointestinal hemorrhage caused by non-variceal bleeding can significantly reduce the BUN / Cr ratio. The hemostatic effect is good, the effect is stable and lasting, and no obvious adverse drug reaction is worthy of clinical application.