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目的探讨乳腺癌患者服用三苯氧胺后卵巢囊肿的发生情况。方法 93例服用三苯氧胺的乳腺癌患者为观察组 ,2 3例未服用三苯氧胺患者为对照组。结果观察组发现卵巢囊肿 18例 ,发生率 19.35 % ,明显高于对照组 ,随访中囊肿缩小或停药后缩小。未绝经和绝经不足 1年的患者 ,其卵巢囊肿发生率为 38.5 % ,月经规律患者发生率为 6 8.2 %。对照组无卵巢囊肿发生。结论卵巢囊肿是乳腺癌患者服用三苯氧胺的常见副作用 ,主要发生于尚未绝经或绝经不足 1年的患者 ,囊肿能自行消失或停药后消失。
Objective To investigate the occurrence of ovarian cysts after taking tamoxifen in breast cancer patients. Methods Ninety-three patients with tamoxifen were enrolled in the observation group and 23 patients without tamoxifen were included in the control group. Results The observation group found 18 cases of ovarian cysts with an incidence rate of 19.35 %, which was significantly higher than that of the control group. During follow-up, the cysts shrank or shrank after drug withdrawal. In patients with no menopause and less than 1 year of menopause, the incidence of ovarian cyst was 38.5 %, and the rate of menstrual regularity was 68.2 %. No ovarian cyst occurred in the control group. Conclusion Ovarian cyst is a common side effect of tamoxifen in patients with breast cancer. It mainly occurs in patients who have not yet undergone menopause or have less than 1 year of menopause. The cyst can disappear on its own or disappear after discontinuation.