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近十年来,对一系列多肽的研究进展十分迅速。这些多肽可调节涉及免疫、炎症和造血细胞系的生长、分化和功能。将这些因子作细胞系培养确证了它们的存在以及与其它因子的区分。克隆产物的应用大大加快了这些因子生物活性的研究,肿瘤坏死因子(TNF)和淋巴毒素(LT)这两种因子最初被发现是由于它们的细胞毒性及抗肿瘤活性,TNF对实验性肿瘤具有显著的作用(肿瘤出血性坏死并消退),引起了人们对其临床应用的极大兴趣。然而,最初在肿瘤患者的应用并未得到相似的抗肿瘤效果,
In the past decade, research on a series of peptides has progressed rapidly. These polypeptides can regulate the growth, differentiation and function of immune, inflammatory and hematopoietic cell lines. The use of these factors as cell line cultures confirms their presence and differentiation from other factors. The use of cloned products has greatly accelerated the study of the biological activity of these factors. The two factors of tumor necrosis factor (TNF) and lymphotoxin (LT) were originally found to be due to their cytotoxicity and anti-tumor activity. TNF has an effect on experimental tumors. The significant effect (hemorrhagic necrosis and regression of the tumor) has caused great interest in its clinical application. However, the initial application in cancer patients did not achieve similar anti-tumor effects.