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目的 探讨急性有机磷农药中毒患者血液白细胞（ＷＢＣ），中性粒细胞（Ｎ） 和Ｃ－ 反应蛋白（ＣＲＰ） 的变化及其临床意义。方法 根据患者入院时中毒的程度设轻度中毒组、中度中毒组、重度中毒组和健康对照组。急性有机磷农药中毒患者在入院的第１ 日、３ 日、７ 日抽静脉血检测。结果 入院第１ 日，中度中毒组和重度中毒组血液ＷＢＣ、Ｎ、ＣＲＰ水平均显著高于健康对照组（ Ｐ＜ ０－０５ 和Ｐ＜０－０１）；第３ 日、第７ 日中度中毒组的血液Ｎ和重度中毒组的血液ＷＢＣ、Ｎ、ＣＲＰ水平仍显著高于健康对照组（Ｐ＜０－０５ 和Ｐ＜ ０－０１）；轻度中毒组与健康对照组比较，除入院第１ 日血液Ｎ 明显升高（ Ｐ＜ ０－０５） 外，其余均无显著差异（Ｐ＞０－０５）。结论 急性有机磷农药中毒患者血液中ＷＢＣ、Ｎ、ＣＲＰ水平的升高与中毒的程度及组织损伤的病理过程相一致。
Objective To investigate the changes of blood leukocyte (WBC), neutrophil (N) and C-reactive protein (CRP) in patients with acute organophosphorus pesticide poisoning and its clinical significance. Methods According to the degree of poisoning on admission, patients were divided into mild poisoning group, moderate poisoning group, severe poisoning group and healthy control group. Acute organophosphorus pesticide poisoning in patients admitted to the first day, 3rd, 7th venous blood test. Results On the first day after admission, the levels of blood WBC, N and CRP in moderate poisoning group and severe poisoning group were significantly higher than those in healthy control group (P <0-05 and P <0-01). On day 3 and day 7 The levels of blood WBC, N and CRP in severe poisoning group were significantly higher than those in healthy control group (P <0-05 and P <0-01). Compared with healthy control group, On the first day after admission, blood N was significantly increased (P <0-05), the rest were no significant difference (P> 0-05). Conclusion The levels of WBC, N and CRP in the blood of patients with acute organophosphorus pesticide poisoning are consistent with the degree of poisoning and the pathological process of tissue injury.