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目的:观察心衰康颗粒对心衰大鼠心室重塑的影响;方法:腹主动脉缩窄建立慢性心衰大鼠模型,放射免疫法测血浆血管紧张素Ⅱ(AngⅡ)、心钠素(ANP)、肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)、内皮素(ET)及酶联免疫法测去甲肾上腺素NE,测左室肥厚度,并进行心脏病理形态学观察;结果:与模型组相比,各给药组大鼠一般体征明显改善,神经体液因子血浆AngⅡ,NE显著降低,心衰康高、中剂量组大鼠血浆TNF-α,IL-6,ET显著降低,各给药组左室肥厚度显著降低;结论:心衰康颗粒能逆转心衰大鼠心室重塑,其调节神经体液因子,细胞因子的作用可能是其机制之一。
Objective: To observe the effect of Xinshukang Granule on ventricular remodeling in rats with heart failure. Methods: Establish a rat model of chronic heart failure with constriction of abdominal aorta and measure plasma angiotensin II (AngII) and atrial natriuretic peptide by radioimmunoassay ( ANP), Tumor Necrosis Factor Alpha (TNF-α), Interleukin-6 (IL-6), Endothelin (ET) and Enzyme-Linked Immunosorbent Assay for Norepinephrine NE, Measure Left Ventricular Hypertrophy, and Perform Pathological Changes of the Heart Observations; Results: Compared with the model group, the general signs of the rats in the administration groups were significantly improved, and the levels of neurohumoral factors plasma AngII and NE were significantly decreased. Plasma TNF-α and IL-6 in rats with heart failure and high doses of moderate-dose The ET decreased significantly, and left ventricular hypertrophy decreased significantly in all groups. CONCLUSION: Xinshukang Granules can reverse ventricular remodeling in rats with heart failure, and its regulation of neurohumoral factors and cytokines may be one of the mechanisms.