论文部分内容阅读
本研究比较大剂量化疗联合或不联合大面积照射预处理方案对恶性淋巴瘤(ML)患者行自体造血干细胞移植(AHSCT)的疗效、预后及安全性的影响。回顾性分析1992年9月至2010年8月在解放军307医院行AHSCT的100例ML患者,根据AHSCT预处理方案不同,分为高剂量化疗组和高剂量放、化疗组,分析3、5、10年的总生存(OS)率、无进展生存(PFS)率和不良反应。结果表明,截止至2011年2月,中位随访时间33.5个月,所有患者造血功能均获重建。高剂量化疗组和高剂量放、化疗组患者白细胞计数恢复至>1.0×109/L的中位时间为(6.0±0.4)d、(8.2±0.4)d,血小板恢复至>20.0×109/L的中位时间为(7.1±0.8)d、(11.4±2.5)d,差异均具有统计学意义(P<0.05)。高剂量化疗组和高剂量放、化疗组OS率分别为3年67.3%、68.9%,5年62.8%、60.6%,10年57.6%、56.2%;PFS率分别为3年63.6%、63.2%,5年59.4%、58.3%,10年50.8%、55.3%,差异均无统计学意义(P>0.05);两组患者发热、感染、出血差异无统计学意义(P>0.05)。结论:自体移植预处理方案中的高剂量放、化疗组较高剂量化疗组造血重建晚,但两组疗效及预后无统计学差异。
This study compared the effects of high-dose chemotherapy with or without large-area irradiation on the efficacy, prognosis and safety of patients with malignant lymphoma (ML) undergoing autologous hematopoietic stem cell transplantation (AHSCT). A retrospective analysis from September 1992 to August 2010 in the People’s Liberation Army 307 Hospital AHSCT 100 cases of ML patients, according to the AHSCT pretreatment program is divided into high-dose chemotherapy group and high-dose radiotherapy and chemotherapy group, analysis of 3,5, 10-year overall survival (OS) rate, progression-free survival (PFS) rate and adverse reactions. The results showed that as of February 2011, the median follow-up time of 33.5 months, all patients were reconstructed hematopoietic function. The median time to recovery of white blood cell count to> 1.0 × 109 / L was (6.0 ± 0.4) days in high-dose chemotherapy group and high-dose radiotherapy and chemotherapy group (8.2 ± 0.4 days), and platelet recovery to> 20.0 × 109 / L The median time was (7.1 ± 0.8) d, (11.4 ± 2.5) d, the differences were statistically significant (P <0.05). The OS rates in high-dose chemotherapy group and high-dose radiotherapy and chemotherapy group were 67.3%, 68.9%, 62.8%, 60.6%, 57.6%, 56.2% in 3 years, 63.6%, 63.2% , 5 years 59.4%, 58.3%, 10 years 50.8%, 55.3%, the difference was not statistically significant (P> 0.05). There was no significant difference between the two groups in fever, infection and bleeding (P> 0.05). Conclusion: The autologous transplantation pretreatment in the high-dose radiotherapy and chemotherapy group was higher than the high-dose chemotherapy group, and the hematopoietic reconstitution was late. However, there was no significant difference between the two groups in curative effect and prognosis.