In the optimum design of the self-propelled combine gearbox, the knowledge of ANN is applied to overcome slow calculation and low design efficiency. We did the normative approach of the charts information,then solved the difficult problems in the design process and get satisfactory results. We also completed three-dimensional design of the gearbox in order to verify the rationality of the design visually. In the optimum design of the self-propelled combine gearbox, the knowledge of ANN is applied to overcome slow calculation and low design efficiency. We did the normative approach of the chart information, then solved the difficult problems in the design process and get satisfactory results We also completed three-dimensional design of the gearbox in order to verify the rationality of the design visually.