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本实验应用大、小鼠全胚胎培养方法研究维生素 C拮抗重铬酸钾对大、小鼠胚胎的发育毒性。结果表明 ,10倍于重铬酸钾浓度的维生素 C可有效地拮抗重铬酸钾对大、小鼠胚胎的发育毒性。加入维生素 C后 ,重铬酸钾浓度分别在15 m g· L- 1和 18mg· L- 1以上时才对大、小鼠胚胎生长发育及形态分化有明显的影响。而在未加入维生素 C时 ,重铬酸钾浓度在 0 .5 mg· L- 1和 1.5 mg· L- 1 ,即可影响大、小鼠胚胎的生长发育。表明维生素 C可有效地拮抗重铬酸钾对大、小鼠胚胎的发育毒性。
In this study, large and small mouse embryo culture method to study the vitamin C antagonism of potassium dichromate on the developmental toxicity of large and mouse embryos. The results showed that vitamin C at a concentration 10 times that of potassium dichromate effectively antagonized the developmental toxicity of potassium dichromate to large and mouse embryos. After addition of vitamin C, the concentration of potassium dichromate at 15 m g · L-1 and 18 mg · L-1 or more, respectively, had significant effects on the growth and morphological differentiation of large and small mice embryos. In the absence of vitamin C, potassium dichromate concentration of 0.5 mg · L -1 and 1.5 mg · L -1, can affect the growth of large and mouse embryos. Vitamin C can effectively antagonize potassium dichromate on the developmental toxicity of large and mouse embryos.