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目的探讨血浆脑钠肽(type B natriuretic peptide,BNP)水平与舒张性心力衰竭并同时存在肾功能不全,心房纤颤间的关系。方法通过对356例心衰患者临床症状,心脏彩色多普勒超声检查和有创血流动力学监测的结果,筛选出确诊的肯定舒张功能不全患者67例。评价肯定的舒张功能不全患者BNP浓度,以及肾功能不全,心房纤颤对BNP浓度的影响。结果肯定的舒张功能不全患者血浆BNP浓度升高,但显著低于收缩功能不全患者,合并心房纤颤,肾功能不全的患者血浆BNP浓度明显升高。结论舒张功能不全的患者血浆BNP浓度也会增加,但程度不如收缩功能不全患者。合并心房纤颤患者血浆BNP浓度会增高,肾功能不全会影响BNP的排泄,血浆BNP浓度也会增高。
Objective To investigate the relationship between plasma BNP levels and diastolic heart failure with renal dysfunction and atrial fibrillation. Methods According to the clinical symptoms, cardiac color Doppler echocardiography and invasive hemodynamic monitoring of 356 patients with heart failure, 67 patients with confirmed diastolic dysfunction were screened out. Evaluation of positive diastolic dysfunction in patients with BNP concentration, and renal insufficiency, atrial fibrillation on BNP concentration. Results Positive diastolic dysfunction in patients with plasma BNP concentrations increased, but significantly lower than patients with systolic dysfunction, atrial fibrillation, renal insufficiency in patients with plasma BNP concentration was significantly increased. Conclusions Diastolic dysfunction in patients with plasma BNP concentration will increase, but to a lesser degree than patients with systolic dysfunction. Patients with atrial fibrillation plasma BNP concentration will be increased, renal insufficiency will affect the excretion of BNP, plasma BNP concentration will increase.