树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。曹雪涛院士科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对lncRNA Dendritic cells (DCs) are important antigen-presenting cells in the immune system. Their maturation and functional status determine the direction and intensity of immune responses. Mammalian genomes are capable of transcribing a large number of long noncoding RNAs (IncRNAs), and their function in the immune system is poorly understood. Academician Cao Xuetao research team associate professor Wang’s group using transcriptome second-generation sequencing high-throughput screening methods, RNA-pulldown, ChIP-seq and other technologies launched lncRNA