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作者对22例大于3cm的单个原发肝细胞癌(HCC)作了新的联合治疗,即先经导管动脉栓塞(TAE),两周后开始作经皮穿刺注射无水酒精(PEI),后者重复6～8次。并比较联合疗法与单独TAE21例的疗效。单独TAE的对肿瘤有效反应部分为10%,其1、2和3年生存率分别为68%、37%和0%,从肝切除获得的标本组织学检查显示肿瘤完全坏死的仅为20%。TAE-PEI联合治疗的有效反应率比单独作TAE的显著提高,为45%(P<0.5),并且1、2和3年生存率也显著延长(P<0.1),分别为100%、85%和85%。联合治疗组肿瘤组织学检查完全坏死率为83%。此外,病例随访中肿瘤的复发率也显著低于单独TAE组(P<
The authors performed a new combination therapy for 22 cases of single primary hepatocellular carcinoma (HCC) larger than 3cm, namely, first catheterized arterial embolization (TAE), and two weeks later for percutaneous injection of absolute alcohol (PEI). Repeat 6 to 8 times. The efficacy of combination therapy with 21 TAE alone was compared. TAE alone had a 10% effective response to tumors, with 1-, 2-, and 3-year survival rates of 68%, 37%, and 0%, respectively. Histological examination of specimens obtained from hepatectomy revealed complete necrosis of tumors of only 20%. . The effective response rate of TAE-PEI combination therapy was significantly higher than that of TAE alone, which was 45% (P<0.5), and the 1-, 2-, and 3-year survival rates were also significantly prolonged (P<0.1), which were 100% and 85, respectively. % and 85%. The total necrosis rate of tumors in the combined treatment group was 83%. In addition, the recurrence rate of tumor during follow-up was also significantly lower than that of TAE alone (P<