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在三乙胺存在下利用三苄基氯化锡和 2 ,6 -吡啶二甲酸 ,以 1∶ 1摩尔比反应 ,合成了七配位二聚体{ ( Ph CH2 ) 2 Sn[2 ,6 -( O2 C) 2 C5H3 N]( CH3 OH) } 2 .通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征 .用 X射线单晶衍射法测定了该化合物的晶体结构 .化合物为三斜晶系 ,P1空间群 ,晶胞参数 a=0 .96 2 5 ( 6 ) nm,b=1 .0 94 7( 9) nm,c=1 .996 ( 3) nm,α=90 .0 0 ( 2 )°,β=87.6 9( 3)°,γ=90 .0 0 ( 3)°,Z=2 ,V=2 .1 0 2 ( 6 ) nm3 ,μ=1 .2 4 8mm- 1 ,F( 0 0 0 ) =1 0 0 0 ,R1 =0 .0 4 76 ,w R2 =0 .0 782 .化合物中 2个锡原子呈七配位畸变五角双锥构型 .生物活性测试结果表明 ,该化合物具有较强的体外抗肿瘤活性 .
In the presence of triethylamine, tribenzyl tin chloride and 2, 6 - pyridinedicarboxylic acid were reacted in a 1: 1 molar ratio to synthesize the heptadecahedron dimer {(Ph CH2) 2 Sn [2, 6 - (O2 C) 2 C5H3 N] (CH3 OH)} 2. Its structure was characterized by elemental analysis, IR and 1H-NMR. The crystal structure of the compound was determined by X-ray single crystal diffraction. Triclinic system, space group P1, cell parameters a = 0.96 2 5 (6) nm, b = 1.0947 (9) nm, c = 1.996 (3) nm, α = 90. 0 0 (2) °, β = 87.6 9 (3) °, γ = 90 .0 0 (3) °, Z = 2, V = 2 .1 0 2 (6) nm3, μ = 1.248 mm - 1, F (0 0 0) = 1 0 0 0, R1 = 0 .0 4 76, w R2 = 0. 782. Two tin atoms in the compound exhibit a seven-coordinate-distorted pentagonal bipyramid configuration. The test results show that the compound has strong antitumor activity in vitro.