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胰岛素抵抗(IR)可能是多种疾病(如冠心病、高血压、糖尿病、肥胖、脑血管意外等)的共同发病基础。近年来有关胰岛素抵抗的病因、发病机制、检测方法、中西医治疗的研究等方面均取得了较大进展。中药大黄及其复方可通过降低瘦素、抵抗素、肿瘤坏死因子-α、游离脂肪酸、增加胰岛素受体数目及胰岛素与受体的结合力、降低胰岛素水平等多环节、多途径、多靶点、多因素改善胰岛素抵抗。
Insulin resistance (IR) may be the common pathogenesis of many diseases (such as coronary heart disease, hypertension, diabetes, obesity, cerebrovascular accidents, etc.). In recent years, considerable progress has been made in the etiology, pathogenesis, detection methods, and research of Chinese and Western medicine treatment of insulin resistance. Traditional Chinese medicine rhubarb and its compound can reduce the levels of leptin, resistin, tumor necrosis factor-α, free fatty acid, increase the number of insulin receptors, and the binding force between insulin and receptor, and decrease insulin level. Many factors improve insulin resistance.