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目的:观察二精方多糖提取物对2型糖尿病模型小鼠的降血糖、血脂的影响。方法:采用高脂高糖饮食喂养后,腹腔注射链脲佐菌素制备2型糖尿病小鼠模型,实施灌胃二精方多糖提取物干预30d后,测定空腹血糖值后进行糖耐量实验,然后测定血清三酰甘油、总胆固醇值、高密度脂蛋白、低密度脂蛋白,血浆糖化血红蛋白。结果:二精方多糖提取物中剂量组,低剂量组能降低空腹血糖、糖耐量、三酰甘油、总胆固醇、低密度脂蛋白含量,升高高密度脂蛋白含量,降低糖化血红蛋白水平;二精方多糖提取物高剂量组能降低空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白含量,升高高密度脂蛋白含量,降低糖化血红蛋白水平。结论:二精方多糖提取物具有改善实验性2型糖尿病小鼠糖代谢和脂代谢的作用。
Objective: To observe the effect of polysaccharide extract of sophorae on glucose-lowering and blood-lipid in type 2 diabetic mice. Methods: The model of type 2 diabetic mice was induced by intraperitoneal injection of streptozotocin (STZ). The rats were administered intragastrically for 30 days with polysaccharide extract of two sperms. After the fasting blood glucose was measured, the glucose tolerance test was carried out. Then, Serum triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein and plasma glycated hemoglobin were measured. Results: The results showed that the content of fasting blood glucose, glucose tolerance, triglyceride, total cholesterol, low density lipoprotein, high density lipoprotein and the level of HbA1c in middle and low dosage groups of Erjing polysaccharide extract were reduced; High-dose polysaccharide extract group can reduce fasting blood glucose, triglyceride, total cholesterol, low density lipoprotein content, increase high-density lipoprotein content, reduce the level of glycosylated hemoglobin. Conclusion: The polysaccharide extract of Erjing can improve glucose metabolism and lipid metabolism in experimental type 2 diabetic mice.