集落刺激因子是一类刺激骨髓多能造血干细胞向粒单系祖细胞集落分化,并使其发育为成熟粒细胞、巨噬细胞的体液性造血因子,是治疗化疗引起的骨髓抑制的有效药物之一。本文回顾了近年来有关集落刺激因子的临床应用相关文献,对临床个体化的选择、恰当的用药时机、疗程、剂量有一定的指导意义。 Colony-stimulating factor is a kind of humoral hematopoietic factor that stimulates bone marrow pluripotent hematopoietic stem cells to differentiate into granulocyte-derived progenitor cells and develops into mature granulocytes and macrophages and is an effective drug for the treatment of chemotherapy-induced myelosuppression one. This article reviews the literature about the clinical application of colony stimulating factor in recent years, which has certain guiding significance for the choice of clinical individual, proper medication timing, treatment course and dosage.