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目的分析性别差异与中国人群肠易激综合征(IBS)发病相关性,探讨性激素在IBS发病中的可能作用,为IBS的干预提供理论基础。方法检索1999年至2010年中国生物医学文献数据库、中国科技期刊全文数据库、中国知网收录的中国国内有关性别差异与IBS发病相关性研究的论文,应用Meta分析方法对有关性别差异与IBS发病相关性的病例对照研究结果进行定量综合分析,Review manager4.2进行一致性检验及合并OR值和95%可信区间的计算。结果共检索到28篇文献,其中符合入选标准的文献5篇,包括IBS患者1334例,对照组9064例。一致性检验χ2=3.84,P>0.10,表明纳入的5篇文献具有同质性。合并OR值为0.79,OR<1,且95%可信区间为0.70～0.89;Z=3.91,P<0.0001。表明中国人群IBS患病存在性别差异(女性患病率高于男性)。纳入Meta分析的各文献性别差异漏斗图基本对称,提示Meta分析结果发表偏倚较小。结论中国人IBS患病存在性别差异,女性患病率高于男性。
Objective To analyze the relationship between sex differences and the incidence of irritable bowel syndrome (IBS) in Chinese population and to explore the possible role of sex hormones in the pathogenesis of IBS, providing a theoretical basis for the intervention of IBS. Methods The articles about the relationship between gender differences and IBS incidence in China, which were collected from China Biomedical Literature Database, China Science and Technology Periodicals Full-Text Database, and CNKI, were searched from 1999 to 2010. Meta-analysis was used to analyze the correlation between gender differences and IBS. Sexual case-control study results were quantitative and comprehensive analysis, Review manager4.2 consistency test and combined OR and 95% confidence interval calculation. Results A total of 28 articles were retrieved, of which 5 met the inclusion criteria, including 1334 patients with IBS and 9064 controls. Consistency test χ2 = 3.84, P> 0.10, indicating that the five included articles were homogeneous. The combined odds ratio was 0.79, OR <1, and the 95% confidence interval was 0.70 to 0.89; Z = 3.91, P <0.0001. This indicates that there is a gender difference in the prevalence of IBS in Chinese population (the prevalence of females is higher than that of males). The gender difference funnel charts of each document included in the meta-analysis are basically symmetrical, which indicates that the published results of the meta-analysis are less biased. Conclusions There are gender differences in IBS prevalence in Chinese and the prevalence of female is higher than that of male.