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成人胰岛与烟酰胺和(或)环孢素A(CsA)共培养并进行胰岛素释放试验、细胞内胰岛素定量和原位细胞凋亡染色,结果表明烟酰胺促进离体胰岛细胞的胰岛素合成和分泌,并能减少胰岛细胞的凋亡,对CsA所致的胰岛细胞毒性有保护作用。
Adult islets were co-cultured with nicotinamide and / or CsA and subjected to insulin release assay, intracellular insulin quantification and in situ apoptosis staining. The results show that nicotinamide promotes insulin synthesis and secretion in isolated islet cells , And can reduce the apoptosis of islet cells, has protective effect on islet cytotoxicity caused by CsA.