自1957年安体舒通作为一种利尿剂应用以来,多数报道是介绍该药与其他利尿剂联合应用,最常用剂量是50—150mg。然而最近已有数篇报道介绍安体舒通大剂量单用的疗效。此文评介肝硬变难治性腹水应用大剂量安体舒通的治疗效果。10例病人均属难治性腹水,运用双克治疗无效。此10例病人安体舒通开始用量每日为300mg,连用5天,如不出现利尿反应,每6天增加100mg,直到最大剂量每日 Since spironolactone was used as a diuretic in 1957, most reports describe the use of this drug in combination with other diuretics. The most commonly used dose is 50-150 mg. However, several reports have recently reported the efficacy of spironolactone at high doses. This article reviews the treatment of cirrhosis refractory ascites with high-dose spironolactone treatment. Ten patients were refractory ascites, the use of two grams of treatment ineffective. The 10 patients starting spironolactone daily dose of 300mg, once every 5 days, if there is no diuretic reaction, an increase of 100mg every 6 days until the maximum daily dose