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目的 观察~(131)Ⅰ对分化型甲状腺癌的治疗效果.方法 40例中晚期分化型甲状腺癌在甲状腺全切、颈部转移灶清扫或切除后作了~(131)Ⅰ内放疗.~(131)Ⅰ示33例有肿瘤残留或远处转移,颈、肺、骨、纵隔和其他分别为20、11、8、9、8处.用药1～15次,每次3.76GBq或7.46GBq(100mCi或200mCi).结果 随访2个月～7年,平均3年.病灶消除20处,好转22处,无效5处.临床治愈28例,好转8例,恶化1例,死亡3例,疗效满意.结论 结合治疗结果讨论~(131)Ⅰ治疗的适应证、影响疗效的因素、注意事项及甲状腺全切的意义和实施,强调了~(131)Ⅰ对分化型甲状腺癌的治疗作用.
Objective To observe the therapeutic effect of ~(131)I on differentiated thyroid carcinoma. Methods: 40 cases of advanced and differentiated thyroid carcinoma were treated with ~(131)I internal radiotherapy after total thyroidectomy, cervical metastases dissection or resection.~( 131)I showed 33 cases of residual tumor or distant metastasis, with 20, 11, 8, 9 and 8 sites of the neck, lung, bone, mediastinum, and others, respectively. They were administered 1 to 15 times, 3.76 GBq or 7.46 GBq each time ( 100mCi or 200mCi). The results were followed up for 2 months to 7 years, with an average of 3 years. 20 lesions were removed, 22 were improved, and 5 were ineffective. 28 cases were clinically cured, 8 cases improved, 1 case deteriorated, and 3 cases died. Conclusions The therapeutic indications of ~(131)I treatment for differentiated thyroid cancer were highlighted by discussing the indications of ~(131)I treatment, the factors affecting efficacy, and the significance and implementation of total thyroidectomy.