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目的:探讨脑欣口服液治疗新生大鼠缺氧缺血性脑损伤的机理。方法:将50只7d龄SD大鼠随机分为5组,即假手术组、模型组、大剂量组、中剂量组、小剂量组,每组10只,造模后按要求灌服相同体积的生理盐水和大、中、小剂量的脑欣口服液。结果:模型组与假手术组比较,GLU、NOS、Ca2+含量升高,P<0.05;大剂量组与模型组比较,GLU、NOS、Ca2+含量显著下降,P<0.05;中剂量组与模型组比较,GLU、Ca2+均显著降低,P<0.05;小剂量组与模型组比较,Ca2+水平显著降低,P<0.05。结论:脑欣口服液抑制新生大鼠缺氧缺血性脑细胞凋亡的机理与降低GLU、NOS及Ca2+有关。
Objective: To explore the mechanism of Naoxin oral liquid in treating neonatal rats with hypoxic-ischemic brain damage. METHODS: Fifty seven-day-old Sprague-Dawley rats were randomly divided into 5 groups: sham operation group, model group, high-dose group, middle-dose group, and low-dose group, 10 in each group. After injection, the same volume was filled as required. The normal saline and large, medium and small doses of brain Xin oral liquid. Results: Compared with the sham group, the GLU, NOS, and Ca2+ levels in the model group were increased, P<0.05. Compared with the model group, the GLU, NOS, and Ca2+ contents in the high-dose group were significantly decreased, P<0.05; the middle-dose group and the model group Compared with the control group, GLU and Ca2+ all decreased significantly, P<0.05; in the low-dose group, compared with the model group, the Ca2+ level decreased significantly, P<0.05. Conclusion: The inhibitory mechanism of Naoxin oral liquid on hypoxic-ischemic brain cell apoptosis in neonatal rats is related to the decrease of GLU, NOS and Ca2+.