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目的 :研究腹腔转移性腺癌用三维立体适形放疗的可行性。方法 :对 2 2例腹腔转移性腺癌病例作三维立体适形放疗。设非共面同中心照射野 6～ 8个 ,靶区剂量 2 0～ 30Gy ,7～ 9天。其中 8例加常规放疗 ,30～ 4 0Gy ,2 1～ 2 8天。结果 :临床症状缓解率为 97 7% ,肿块有不同程度退缩 ,总有效率为 77 3% (17/ 2 2 )。治疗前肿块体积小于 5cm× 5cm× 5cm者疗效明显优于大于 5cm× 5cm× 5cm者 (P <0 0 2 5 )。中位生存月数为 7个月 ,1年生存率达 2 2 7% (5 / 2 2 )。加常规照射者疗效无明显提高 (P >0 1) ,放射性损伤却明显增加 ,总体损伤率为 18 1% (4/ 2 2 )。结论 :大多数患者可以耐受三维立体适形放疗 ,通过治疗可改善生存质量 ,适当延长生存期 ,但加用常规照射并不能提高疗效 ,反而增加放射性损伤
Objective: To study the feasibility of three-dimensional conformal radiotherapy for peritoneal metastatic adenocarcinoma. Methods: Twenty-two patients with peritoneal metastatic adenocarcinoma underwent three-dimensional conformal radiotherapy. The non-coplanar center with 6 to 8 irradiation field, the target dose 20 ~ 30Gy, 7 to 9 days. Among them, 8 cases received routine radiotherapy, 30 to 40 Gy, 21 to 28 days. Results: The rate of clinical symptom relief was 97.7%. The mass of the tumor had a degree of withdrawal with a total effective rate of 77.3% (17/22). Before the treatment of tumor volume less than 5cm × 5cm × 5cm were significantly better than those larger than 5cm × 5cm × 5cm (P <0 0 2 5). The median survival time was 7 months, and the 1-year survival rate was 227% (5/2 2). Compared with conventional irradiation, the therapeutic effect was not significantly improved (P> 0 1), radioactive injury was significantly increased, the overall injury rate was 18 1% (4/2 2). Conclusion: Most patients can tolerate three-dimensional conformal radiotherapy, which can improve the quality of life and prolong the survival time appropriately. However, adding conventional irradiation does not improve the curative effect, but increases the radioactive injury