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目的探讨腺苷蛋氨酸治疗药物性肝病的疗效。方法治疗组 3 2例 ,在以甘利欣与能量合剂等护肝药物治疗的基础上同时加用腺苷蛋氨酸 ;对照组 3 0例 ,基础护肝药物及疗程与治疗组相同。观察并比较肝功能等生化指标的变化及副作用。结果治疗 4周后 ,治疗组 AST、TBi L、r-GT、AL P的改善情况及复常率明显优于对照组 ( P<0 .0 1) ;治疗组显效率及总有效率分别为 75 .0 %和 10 0 % ,明显高于对照组的 5 0 .0 %与 86.7% ( P<0 .0 5 )。结论腺苷蛋氨酸治疗药物性肝病具有较好的疗效。
Objective To investigate the therapeutic effect of adenosine methionine on drug-induced liver disease. Methods Thirty-two patients in the treatment group were treated with adenosylmethionine on the basis of Gan Lixin and energy mixture and other liver protection drugs. The control group of 30 patients with the same liver-protecting drugs and the same course of treatment as the treatment group. Observed and compared changes in liver function and other biochemical indicators and side effects. Results After 4 weeks of treatment, the improvement and normalization rate of AST, TBiL, r-GT and ALP in the treatment group were significantly better than those in the control group (P <0.01). The effective rate and total effective rate in the treatment group were 75.0% and 100%, respectively, which were significantly higher than those of the control group (50.0% vs 86.7%, P <0.05). Conclusion adenosine methionine treatment of drug-induced liver disease has a good effect.