我院1975—1988年收治经病理证实Dubin-Johnson综合征6例,兹报道如下。6例中男性5例,女性1例。发病年龄14～24岁,平均21岁。出现黄疸到确诊时间为3月～13年。多于劳累、感染、受凉后发作。症状有皮肤及巩膜黄染、恶心、呕吐、乏力、右上腹痛,腹泻每日1～4次,肝区触痛,肝肋下触及1～2cm。实验室检查总胆红素25.8～102.6μmol/L,直接胆红素12.5～41.9μmol/L,凡登白试验呈速性或双相反应。余肝功能正常,其中1例HB_sAg From 1975 to 1988 in our hospital admitted to the pathology confirmed Dubin-Johnson syndrome in 6 cases, are reported below. 6 cases of male 5 cases, 1 female. The age of onset 14 to 24 years old, average 21 years old. Jaundice appears to confirm the time for 3 months to 13 years. More than tired, infected, cold attack. Symptoms of skin and sclera yellow dye, nausea, vomiting, fatigue, right upper quadrant pain, diarrhea 1 to 4 times daily, liver tenderness, liver ribs touch 1 ~ 2cm. Laboratory tests of total bilirubin 25.8 ~ 102.6μmol / L, direct bilirubin 12.5 ~ 41.9μmol / L, Vandenbai test was rapid or biphasic reactions. I liver function was normal, including 1 case of HB_sAg