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目的 复习胃食管返流性疾病(GERD)诊断与治疗的最新进展.资料与方法 经国立医学图书馆光盘检索了包括1993年以前的有关英文文献报告.参照所有报告的目录及复习杂志刊登的文章,搜寻出更多的资料.在疗效评估中,首先考虑随机研究,最先采用双盲安慰剂对照试验.当其他资料无法获得时可选用摘要、非随机试验和非英文出版物.结果 病史资料和体检所获信息提示GERD发生于许多病人中.使用内窥镜检查或X线气钡造影评估粘膜损伤,是早期诊断GERD的重要手段.内窥镜检查为组织学研究提供被检组织,尤其在Barrett′s食管更为适宜.长期食管pH监测对决定胃酸返流的存在和回流量最为有用.对GERD患者应建议改变生活方式、使用抗酸剂和抗回流药.H_2受体拮抗剂可使32%～83%的GERD患
OBJECTIVE: To review the latest progress in the diagnosis and treatment of gastroesophageal reflux disease (GERD) .Materials and MethodsAccording to the National Library of Medicine CD-ROM, relevant English literature reports including before 1993 were retrieved.Refer to the catalog of all the reports and the articles published in the review magazine , To find out more information in the efficacy evaluation, the first to consider randomized studies, the first double-blind placebo-controlled trial.When the other information is not available when available abstracts, non-randomized trials and non-English publications .Results Historical data And physical examination of the information prompted GERD occurred in many patients.Use of endoscopy or X-ray barium evaluation of mucosal damage is an important means of early diagnosis of GERD Endoscopy provides tissue for histological examination of tissues, especially In Barrett’s esophagus is more appropriate.Long-term esophageal pH monitoring is most useful in determining the presence and return of gastric acid reflux.For GERD patients should be proposed to change the way of life, the use of antacids and anti-reflux drugs.H 2 receptor antagonist Make 32% ~ 83% of GERD patients