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二聚细辛醚是具有降脂作用的新成分,小鼠和大鼠ig、iv后,血中放射性—时间曲线符合开放二室模型。ig和iv后的平均t 1/2β:小鼠分别为107.1±7h、107.5±5h;大鼠101±7.9h、102.9±6.4h。Vd:小鼠为11.9±2.3L/kg、7.9±3.7L/kg;大鼠5.0±0.21/kg、6.0±3.4L/kg。该药吸收快,分布迅速、广泛,体内消除较缓慢。21d内从尿和粪中排泄分别为96.7％和1.02％。血浆蛋白结合率为48％。尿液提取物经TLC放射自显影和液体闪烁仪测定结果主要以原形药物排出,并有代谢产物。
Dimerized asarone has a lipid-lowering effect of new components, mice and rats ig, iv, the blood radioactive - time curve in line with the open two-compartment model. Average t 1 / 2β after ig and iv: mice were 107.1 ± 7 h, 107.5 ± 5 h, 101 ± 7.9 h, 102.9 ± 6.4 h, respectively. Vd: 11.9 ± 2.3 L / kg for mice, 7.9 ± 3.7 L / kg for rats; 5.0 ± 0.21 / kg for rats, 6.0 ± 3.4 L / kg. The drug absorption fast, rapid distribution, extensive, more slowly eliminate the body. Excretion from urine and feces was 96.7% and 1.02% respectively in 21d. Plasma protein binding was 48%. Urine extracts by TLC autoradiography and liquid scintigraphy results mainly to the prototype drug discharge, and metabolites.