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创新霉素是由我国济南土壤中分离出的一株游动放线菌产生的新抗生素,具有新的化学结构,创新霉素在人体内对大肠杆菌引起的感染有较好的疗效,本文报导其体内外抗菌活性,在人体内血尿浓度及大鼠体内分布的试验结果。 材料和方法 (1)菌种:一部分为实验室保存菌株,一部分为临床分离菌株(北京市分离),经初步鉴别后,冷冻干燥保存。 (2)药物来源:创新霉素为本所及大连制药厂生产,为淡黄色的较纯制品,四环素及庆大霉素由药品检定所供给,其他为市售商品。 (3)抑菌浓度的测定:使用试管及平皿二倍稀释法。 (4)半数有效剂量的计算:小鼠感染后,
Innovative neomycin is a new antibiotic produced by a swimming actinomycete isolated from the soil of Jinan of our country. It has a new chemical structure. Neomycin has a good curative effect on Escherichia coli-induced infections in humans. Its antibacterial activity in vitro and in vivo, the concentration of hematuria in human body and the distribution of test results in rats. Materials and methods (1) strains: a part of the laboratory preservation strains, part of the clinical isolates (Beijing separation), after initial identification, freeze-dried preservation. (2) Source of drugs: Neomycin is produced by Dalian Pharmaceutical Factory and is a light yellow purer product. Tetracycline and gentamicin are supplied by the drug testing institute while others are commercial products. (3) Determination of antibacterial concentration: the use of tubes and plates double dilution method. (4) Calculation of half effective dose: After infection in mice,