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目的探讨左旋卡尼丁(L-CN)对急性心肌梗死患者肌钙蛋白T(cTnT)和C-反应蛋白(CRP)含量的影响。方法2004年1~12月在沈阳医学院附属沈洲医院住院治疗的急性心肌梗死(AMI)患者25例,为试验组,给予L-CN4.0g/d,共用7d;另选AMI患者25例作为对照组。所有患者于用药前、用药第3天后,用药结束后检测cTnT和CRP。并于用药前和用药结束后行超声心动图检查及心肌灌注显像分析。结果用药前cTnT和CRP含量两组间差异无显著性意义(P>0.05)。用药第3天后试验组cTnT和CRP较对照组下降但差异无显著性意义;用药结束后试验组cTnT和CRP较对照组显著减低(P<0.05)。试验组在用药后左心室射血分数(LVEF)较对照组明显改善(P<0.05),心肌缺损面积缩小(P<0.05)。结论心肌梗死时给予L-CN治疗可降低血循环中cTnT和CRP含量,有利于心肌修复,缩小梗死面积。
Objective To investigate the effects of L-CN on the expression of troponin T (cTnT) and C-reactive protein (CRP) in patients with acute myocardial infarction. Methods Twenty-five patients with acute myocardial infarction (AMI) who were hospitalized in Shenyang Chau Hospital, Shenyang Medical College from January to December 2004 were given L-CN (4.0g / d) for 7 days. Another 25 patients with AMI As a control group. All patients before treatment, after the first 3 days of treatment, cTnT and CRP after the end of the test. Echocardiography and myocardial perfusion imaging were performed before and after treatment. Results Before treatment, the contents of cTnT and CRP had no significant difference between the two groups (P> 0.05). The cTnT and CRP in the experimental group decreased after 3 days of treatment compared with the control group, but there was no significant difference between the two groups. The cTnT and CRP of the experimental group decreased significantly (P <0.05) after the treatment. The left ventricular ejection fraction (LVEF) of the experimental group was significantly improved (P <0.05) and the myocardial defect area was reduced (P <0.05) after treatment. Conclusions The administration of L-CN in myocardial infarction can reduce the content of cTnT and CRP in the blood circulation, which is good for myocardial repair and infarction area reduction.