为探讨血管活性物质在冠状动脉痉挛发生机制中的作用,本文观测了36例冠心病病人血浆内皮素(ET)和6—酮前列腺素F_(1α)(6—keto—PGF_(1α))的变化,结果发现:冠心病组与正常组比较,血ET明显增高,同时6—keto—PGF_(1α)显著下降,尤以不稳定型心绞痛和急性心肌梗塞组明显。提示冠心病病人存在血管内皮细胞分泌的血管活性物质平衡失调,此可能会导致冠状动脉舒缩障碍和发生痉挛,与不稳定性心绞痛的发生有关。 In order to investigate the role of vasoactive substances in the pathogenesis of coronary artery spasm, we observed the changes of plasma endothelin (ET) and 6-keto-PGF_ (1α) in 36 patients with coronary heart disease The results showed that compared with the normal group, ET in ET patients was significantly increased, while 6-keto-PGF_ (1α) was significantly decreased, especially in patients with unstable angina pectoris and acute myocardial infarction. Tip coronary heart disease patients with vascular endothelial cells excrete vasoactive substances imbalance, which may lead to coronary artery systolic dysfunction and spasm, and the occurrence of unstable angina.