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本文利用闭合式颅骨开窗的方法制成脑微循环小室,以显微镜摄像系统连续观察双侧颈总动脉阻塞前后软脑膜微循环的变化,发现双侧颈总动脉阻塞后,软脑膜动脉管径和平均动脉压分别增加了40％和58％;静脉内血球流速减少至原值的70％;软脑膜动脉对动脉血二氧化碳浓度升高及低血压所引起的扩张反应受到明显抑制。实验结果提示:双侧颈总动脉阻塞后,虽然脑动脉明显扩张、血压上升。仍不足以代偿由于脑局部灌注压的下降所造成的脑血流量减少。提示双侧颈总动脉阻塞时,脑血流的自动调节功能受到严重损害。
In this paper, closed cranial fenestration method was used to make microcatheter microcirculation. Microscope imaging system was used to observe the change of pia mater microcirculation before and after bilateral common carotid artery occlusion. After bilateral common carotid artery occlusion, And mean arterial pressure were increased by 40% and 58%, respectively. The venous blood flow was reduced to 70% of the original value. The leptomeningeal artery was significantly inhibited by the increase of arterial carbon dioxide concentration and hypotension. Experimental results suggest that: bilateral carotid artery obstruction, although significant expansion of the cerebral artery, blood pressure. Still not enough to compensate for the decline in cerebral perfusion pressure caused by decreased cerebral blood flow. Tip bilateral carotid artery occlusion, cerebral blood flow auto-regulation function was severely damaged.