论文部分内容阅读
目的观察小容量高渗晶体等渗胶体混合溶液对创伤失血性休克患者的早期容量复苏效果。方法将我科收治的48例早期轻、中度创伤失血性休克患者,随机分为两组,每组24例。通过外周血管在15～20 min 内快速输注250ml 研究药物(贺苏,7.2%氯化钠/6%羟乙基淀粉200/0.5注射液)或对照药物(贺斯,0.9%氯化钠/1%羟乙基淀粉200/0.5溶液)。在给药前、给药后0.5、10、15、20、25、30 min 测定患者的血压、脉搏和休克指数;在研究开始前和给药后30 min 各采集1次外周血样本,并检测血常规、血 Na~+、Cl~-和凝血常规。结果研究组收缩压在给药后0、5、10、15、20、25、30 min 均显著高于对照组(P<0.01),舒张压在给药后0、5、10、15 min 内均显著高于对照组(P<0.05),休克指数在给药后均显著低于对照组(P<0.05)。研究组在给药后血 Na~+、Cl~-高于对照组(P<0.01),但其平均浓度在正常参考值范围内。研究组与对照组凝血功能、血常规指标差异均无统计学差异。结论小容量高渗晶体等渗胶溶液在创伤失血性休克患者早期血流动力学快速恢复作用上有良好的效果且安全性良好。
Objective To observe the early capacity recovery of patients with traumatic hemorrhagic shock by using small volume and high-osmolarity isotonic gel mixed solution. Methods Forty-eight patients with early mild to moderate traumatic hemorrhagic shock admitted to our department were randomly divided into two groups (24 in each group). Rapid infusion of 250 ml of study drug (He Su, 7.2% sodium chloride / 6% hydroxyethyl starch 200 / 0.5 injection) or control drug (Hessian, 0.9% sodium chloride / 1% hydroxyethyl starch 200 / 0.5 solution). Blood pressure, pulse rate and shock index were measured at 0.5, 10, 15, 20, 25 and 30 min after the administration. Peripheral blood samples were collected before the start of the study and 30 min after the administration, Blood, blood Na ~ +, Cl ~ - and coagulation routine. Results Systolic blood pressure in study group was significantly higher than that in control group at 0, 5, 10, 15, 20, 25 and 30 min after administration (P <0.01) (P <0.05). The shock index was significantly lower than that of the control group after administration (P <0.05). The study group after administration of blood Na ~ +, Cl ~ - higher than the control group (P <0.01), but the average concentration within the normal reference range. There was no significant difference in coagulation function and blood routine between study group and control group. Conclusion Small volume hypertonic crystal isotonic solution has good effect and good safety in early hemodynamic recovery in patients with traumatic hemorrhagic shock.