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目的:探讨放疗联合含羟基喜树碱化疗方案根治鼻咽癌的疗效。方法:对54 例鼻咽癌患者采用放疗联合含羟基喜树碱化疗方案(实验组),36 例鼻咽癌患者采用单纯放疗(对照组),对两者疗效与毒副作用作一比较。结果:实验组有效率为88.8 %(48/54),对照组有效率为83.3 %(30/36),两组比较差异无显著性(P>0.05);但实验组完全缓解率为40.7 %(22/54),对照组为27.7 %(10/36),差异有显著性(P<0.05)。结论:放疗联合含羟基喜树碱化疗方案根治鼻咽癌值得推广应用。
Objective: To investigate the curative effect of radiotherapy combined with hydroxycamptothecin chemotherapy in the treatment of nasopharyngeal carcinoma. Methods: 54 patients with nasopharyngeal carcinoma were treated with radiotherapy combined with hydroxycamptothecine (experimental group), and 36 patients with nasopharyngeal carcinoma were treated with radiotherapy alone (control group). The curative effect and toxicity were compared between the two groups. Results: The effective rate was 88.8% (48/54) in the experimental group and 83.3% (30/36) in the control group, with no significant difference between the two groups (P> 0.05). However, the complete remission rate was 40.7% (22/54) in the control group and 27.7% (10/36) in the control group, with significant difference (P <0.05). Conclusion: radiotherapy combined with hydroxycamptothecin chemotherapy regimen for the treatment of nasopharyngeal carcinoma deserved to be widely used.