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目的探讨依达拉奉注射液治疗急性脑梗死的临床疗效情况。方法将80例急性脑梗死患者随机分为治疗组和对照组,治疗组40例在奥扎格雷注射液、疏血通注射液基础用药之上,另加用依达拉奉注射液+0.9%氯化钠注射液100 ml静脉滴注,2次/d,使用时间14 d;对照组40例仅应用奥扎格雷注射液、疏血通注射液基础用药,治疗前及治疗后2周分别对两组患者进行神经功能评分(NIHSS)。结果依达拉奉注射液治疗急性脑梗死能够有效地清除自由基、保护脑细胞、改善神经功能缺损,抑制缺血半暗带处神经细胞的迟发性死亡、脂质过氧化能、细胞水肿、坏死、凋亡等。治疗组治疗后第14天神经功能缺损程度评分较前明显降低(P<0.05)。结论急性脑梗死患者应用依达拉奉能够显著改善患者神经功能缺损程度,临床治疗效果显著,值得临床推广应用。
Objective To investigate the clinical efficacy of edaravone injection in the treatment of acute cerebral infarction. Methods Eighty patients with acute cerebral infarction were randomly divided into treatment group and control group. In the treatment group, 40 cases were treated with Ozagrel injection and Shuxuetong injection, with the addition of edaravone injection plus 0.9% Sodium chloride injection 100 ml intravenous infusion, 2 times / d, the use of time 14 d; control group 40 cases only the application of ozagrel injection, Shuxuetong injection basic medication, before treatment and 2 weeks after treatment were Two groups of patients were scored for neurological function (NIHSS). Results Edaravone injection in acute cerebral infarction can effectively eliminate free radicals, protect brain cells, improve neurological deficits, inhibit the delayed death of neurons in ischemic penumbra, lipid peroxidation, cell edema , Necrosis, apoptosis and so on. The score of neurological deficit in the treatment group on the 14th day after treatment was significantly lower than that before (P <0.05). Conclusion The application of edaravone in patients with acute cerebral infarction can significantly improve the degree of neurological deficit in patients with clinical treatment of significant effect, it is worthy of clinical application.