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目的评价卡维地洛治疗急性心肌梗死早期快速心律失常的疗效和耐受性。方法入选急性心肌梗死早期快速心律失常的患者59例,入选患者均给予心电监护,并在发现快速心律失常24h内和出院后1、3个月做24h动态心电监测。在常规药物治疗的基础上随机分为2组,分别给予卡维地洛和美托洛尔。结果卡维地洛和美托洛尔均能控制急性心肌梗死早期快速心律失常,但卡维地洛组明显优于美托洛尔组,差异有显著性(P<0.05)。治疗第3个月与第1个月比较卡维地洛组可进一步减少心律失常的发生,差异有显著性(P<0.05)。而美托洛尔组无明显变化(P>0.05)。结论卡维地洛可以很好的控制急性心肌梗死早期的快速心律失常,降低猝死和恶性心血管事件的发生。
Objective To evaluate the efficacy and tolerability of carvedilol in the treatment of early tachyarrhythmia in acute myocardial infarction. Methods Fifty-nine patients with early tachyarrhythmia in acute myocardial infarction were enrolled. All the patients were enrolled in the electrocardiogram (ECG) monitoring. 24h ambulatory ECG was detected within 24h after the discovery of tachyarrhythmia and within 1 month and 3 months after discharge. On the basis of routine drug treatment, they were randomly divided into 2 groups, which were given carvedilol and metoprolol respectively. Results Both carvedilol and metoprolol could control early tachyarrhythmia in acute myocardial infarction, but the carvedilol group was superior to metoprolol group (P <0.05). Carvedilol group at the third month of treatment and the first month of treatment could further reduce the arrhythmia, the difference was significant (P <0.05). Metoprolol group had no significant change (P> 0.05). Conclusion Carvedilol can control early tachyarrhythmia in acute myocardial infarction and reduce the incidence of sudden death and malignant cardiovascular events.