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乙型肝炎病毒(HBV)变异与暴发性乙型肝炎(FHB) 一贯认为FHB的发病机理是由于宿主免疫系统对乙型肝炎病毒(HBV)感染的过度应答,但导致免疫异常的原因不明。分子流行病学调查发现有些FHB是由变异毒株所引起。HBV-DNA前C/C区变异在FHB常见,在急性肝炎较少出现,提示病毒的变异与疾病的发展的结局密切相关。另外,有报道急性肝炎潜伏期的丈夫把HBV变异毒株传给妻子,妻子得了FHB。相同的病毒株引起不同的结果,提示其发生机理也与个体免疫应答有关。
Hepatitis B virus (HBV) mutations and fulminant hepatitis B (FHB) The pathogenesis of FHB has long been thought to be due to an over-response of the host’s immune system to hepatitis B virus (HBV) infection, but the cause of the immunological abnormalities is unknown. Molecular epidemiological investigations revealed that some FHBs are caused by mutated strains. Pre-C / C mutation of HBV-DNA is common in FHB and less in acute hepatitis, suggesting that the variation of HBV is closely related to the outcome of the disease. In addition, husbands who reported the acute phase of hepatitis had their HBV variant strains passed to their wives and their wives had FHBs. The same strains cause different results, suggesting that their pathogenesis is also related to the individual’s immune response.