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目的了解中国b型流感嗜血杆菌(Hib)疫苗加强免疫前后的免疫保护水平,为制定中国Hib疫苗免疫策略提供参考。方法在2个县选择已完成3剂Hib疫苗接种的健康儿童作为研究对象,分别于加强免疫前后采血检测抗Hib荚膜多糖抗体。结果在119名纳入研究对象中,加强免疫前、后血清抗Hib抗体浓度≥0.15μg/ml的比例均为100%;抗体浓度≥1.0μg/ml的比例分别为88.2%(105/119)、96.6%(115/119)(χ~2=6.01,P=0.01);抗体几何平均浓度(GMC)分别为3.60(95%CI:3.03-4.28)μg/ml、6.77(95%CI:5.96-7.68)μg/ml(t=5.93,P=0.00)。结论 Hib疫苗加强免疫能诱导免疫记忆反应,产生更高比例的长期保护力和更高的抗体水平。
Objective To understand the immune protection level of Chinese Hib vaccine before and after boosting, so as to provide a reference for the development of Chinese Hib vaccine immunization strategy. Methods Healthy children who had completed 3 doses of Hib vaccine were selected as research subjects in 2 counties, and anti-Hib capsular polysaccharide antibodies were collected before and after boosting. Results Among the 119 subjects enrolled in the study, the percentages of serum anti-Hib antibodies ≥ 0.15μg / ml before and after boosting were both 100%; the antibody concentrations ≥1.0μg / ml were 88.2% (105/119) (95% CI: 3.03-4.28) μg / ml and 6.77 (95% CI: 5.96-I) were 96.6% (115/119) (χ 2 = 6.01, 7.68) μg / ml (t = 5.93, P = 0.00). Conclusion Hib vaccine boosted immunity can induce immune memory response, resulting in a higher proportion of long-term protection and higher antibody levels.