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目的研究尿毒症患者甲状腺激素水平,以指导其治疗。方法将尿毒症患者分为血液透析组和非透析组,采用放射免疫法测定血液中甲状腺激素水平,并与正常对照组相比较。结果尿毒症患者的T3、T4均显著低于正常对照组(P<0.01),而TSH差异无统计学意义(P>0.05);尿毒症病人中血液透析组血液中甲状腺激素水平减低少于非透析组(P<0.01),而TSH差异无统计学意义。结论尿毒症患者易发生甲状腺功能减退,血液透析治疗能减少其发生。
Objective To study the thyroid hormone level in patients with uremia to guide its treatment. Methods Patients with uremia were divided into hemodialysis group and non-dialysis group. The level of thyroid hormone in the blood was determined by radioimmunoassay and compared with the normal control group. Results The levels of T3 and T4 in patients with uremia were significantly lower than those in normal controls (P <0.01), but no significant differences were found in TSH between the two groups (P> 0.05). The serum levels of thyroid hormone in patients with uremia decreased less than those in patients without uremia Dialysis group (P <0.01), while TSH difference was not statistically significant. Conclusions Patients with uremia are prone to have hypothyroidism and hemodialysis therapy can reduce their occurrence.