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目的探讨基于色素内镜诊断和黏膜下剥离术治疗早期胃癌的临床疗效及安全性。方法收集2012年2月-2014年12月来该院就诊的早期胃癌疑似患者184例,统一给予色素内镜诊断,最终经病理确诊169例,随机分为试验组84例和对照组85例,试验组给予内镜黏膜下剥离术治疗,对照组给予常规开腹治疗,观察2组患者治疗效果和安全性。结果 184例早期胃癌疑似患者经色素内镜诊断阳性152例,确诊145例,其中阳性似然比1.838,阴性似然比0.266,诊断正确率为83.15%;试验组患者治疗有效率高于对照组,而并发症发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论色素内镜诊断早期胃癌具有较高的临床诊断率,辅助黏膜下剥离术治疗具有显著的临床疗效和安全性。
Objective To investigate the clinical efficacy and safety of endoscopic diagnosis and submucosal dissection for early gastric cancer. Methods A total of 184 patients with early gastric cancer who were admitted to our hospital from February 2012 to December 2014 were enrolled. One hundred and sixty-four patients with suspected gastric cancer were diagnosed by chromoendoscopy. One hundred and sixty-six patients were randomly divided into experimental group (n = 84) and control group (n = 85) The experimental group was treated with endoscopic submucosal dissection and the control group with conventional laparotomy. The therapeutic effect and safety of the two groups were observed. Results A total of 184 patients with early gastric cancer were diagnosed by chromoendoscopy as positive 152 cases and 145 cases as diagnosed. The positive likelihood ratio was 1.838 and the negative likelihood ratio was 0.266, the diagnostic accuracy rate was 83.15%. The treatment efficiency in the experimental group was higher than that in the control group , While the incidence of complications was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Endoscopic diagnosis of early gastric cancer with high clinical diagnosis rate, assisted submucosal dissection has significant clinical efficacy and safety.