论文部分内容阅读
为探讨马桑内酯长期致痫对脑的影响,本文在60只大鼠(致痫组和非致痫组各半),观察了马桑内酯致癫痫发作次数的不同,大脑内神经元和胶质细胞密度的变化,小脑内蒲肯野氏细胞密度的变化,并配合经典的高尔基染色和免疫组化染色等定性指标。初步认为马桑内酯长期致痫对脑是有影响的,这种影响是逐渐发生的,其明显变化表现为大脑胶质细胞的增生和小脑深部蒲肯野氏细胞的缺失。上述变化多发生在致癫5.5月,以6.5月最明显。本结果可为马桑内酯在临床的合理使用提供解剖学依据。
In order to investigate the effect of long-term ephedrine on the brain, the effects of epididymal on the number of epileptic seizures in 60 rats (epilepsy group and non-epileptic group) And glial cell density changes, Purkinje cell density changes in the cerebellum, and with the classic Golgi staining and immunohistochemical staining and other qualitative indicators. Initially that the long-term epilepsy ephedrine influence on the brain, this effect is gradually occurring, the obvious changes in the performance of the glial cells proliferation and the absence of deep Purkinje cells. The above changes occurred in induced epilepsy 5.5 months to 6.5 months the most obvious. This result may provide an anatomical basis for the rational use of corundolactone in clinical practice.