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目的:探讨静脉使用多索茶碱联合布地奈德雾化吸入对慢性阻塞性肺疾病急性加重期(AECOPD)的疗效。方法:对照组进行常规治疗,观察组在常规治疗的基础上用多索茶碱注射液联合布地奈德氧驱动雾化吸入治疗,1次/d,14 d为1疗程。结果:观察组和对照组对比,在临床症状及体征积分、6MWD、FEV1/FVC(%)、FEV1占预计值的百分比(%)方面,两组比较有统计学差异(P<0.05)。结论:多索茶碱静脉滴注联合布地奈德雾化吸入治疗慢性阻塞性肺病急性加重期可以改善患者呼吸困难,提高运动耐量、改善肺功能。
Objective: To investigate the efficacy of intravenous doxofylline combined with budesonide inhalation on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: The control group was treated routinely. The observation group was treated with Doxofylline injection combined with budesonide oxygen inhalation, once a day for 14 days, on the basis of routine treatment. Results: There were significant differences between the two groups in terms of clinical symptoms and signs, 6MWD, FEV1 / FVC (%) and FEV1 percentage of predicted value (P <0.05). Conclusion: Doxofylline intravenous infusion combined with budesonide inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease can improve dyspnea, improve exercise tolerance and improve pulmonary function.