论文部分内容阅读
目的 研究大肠肿瘤p5 3蛋白表达及其与临床预后及复发的关系。方法 应用免疫组化ABC法对 89例大肠癌、12例腺瘤、10例非瘤性息肉、12例大肠癌旁正常粘膜的石蜡标本切片进行 p5 3蛋白检测。 结果 89例大肠癌中有 5 6例 p5 3阳性 ;只有 1例呈现重度异型增生的腺瘤表现 p5 3阳性 ;p5 3染色强度与肿瘤的恶性程度及浸润、扩散程度呈正相关 ;p5 3阳性者复发率高且无瘤生存率低。结论 在大肠腺瘤向大肠癌转化过程中 p5 3基因突变起了促进作用。p5 3蛋白检测及其染色强度可作为预测大肠癌预后及复发的重要指标
Objective To study the expression of p53 protein in colorectal tumors and its relationship with clinical prognosis and recurrence. Methods Immunohistochemical ABC method was used to detect p53 protein in 89 cases of colorectal cancer, 12 cases of adenoma, 10 cases of non-tumor polyps, and 12 cases of normal mucosa around paratumor. Results There were 59 cases of p53 in 89 cases of colorectal carcinoma. Only one case of adenoma with severe dysplasia showed p53 positive. The intensity of p53 staining was positively correlated with the degree of malignancy and degree of invasion and spread of p53; The recurrence rate is high and the disease-free survival rate is low. Conclusion The mutation of p53 gene plays an important role in the transformation of large intestine adenoma to colorectal cancer. Detection of p53 protein and its staining intensity can be used as an important predictor of prognosis and recurrence of colorectal cancer