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治疗糖尿病的中药复方中，黄连是其中一味，经药效学研究证明，其总生物碱为有效部位，所含的多种生物碱中主要成分是小檗碱、棕榈碱、药根碱和黄连碱等。为了分析鉴定黄连总碱中微量生物碱，运用ESI-MS/MS，FAB-MS/MS以及LC-MS/MS等各种质谱方法对由甲醇提取的总碱部分进行了
In traditional Chinese medicine prescriptions for the treatment of diabetes, Coptis chinensis is one of them. Pharmacodynamic studies have shown that its total alkaloids are effective sites. The main components contained in various alkaloids are berberine, palmitine, jatrorrhizine and berberine. Alkali and so on. In order to analyze and identify trace alkaloids in total alkaloids from Coptis chinensis, the total alkali fraction extracted from methanol was analyzed by various mass spectrometry methods such as ESI-MS/MS, FAB-MS/MS, and LC-MS/MS.