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建立了甘草酸标准样品的研制方法。采用硅胶柱色谱结合重结晶方法对甘草酸进行分离制备,UV、IR、MS和NMR等方法对甘草酸进行结构表征,并进行了均匀性、稳定性检验,经国内8个具有分析资质的实验室进行协同定值,甘草酸标准样品的标准值为99.29%,置信度95%的不确定度值为0.12%。该标准样品达到国家标准样品的技术要求,可用于有关甘草酸检测方法的校正和相关产品的质量控制。
The establishment of glycyrrhizic acid standard sample development method. Glycyrrhizic acid was separated and purified by silica gel column chromatography and recrystallization method. The structure of glycyrrhizic acid was characterized by UV, IR, MS and NMR. The homogeneity and stability of Glycyrrhizic acid were tested. Eight domestic samples with analytical qualifications Room for collaborative setting, glycyrrhizic acid standard sample of the standard value of 99.29%, 95% confidence level of uncertainty of 0.12%. This standard sample meets the technical requirements of national standard samples and can be used for the calibration of glycyrrhizic acid detection methods and the quality control of related products.