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一种用微量血中头孢唑啉的高效液相色谱测定方法研究头孢唑啉钠静滴用药在小儿时期的药物动力学。本法从头孢拉定作内标物。C18径向加压色谱柱,0,01M法醋酸钠/甲醇(75/25)作流动相,254nm检测。方法学评价表明该方法灵敏度、精密度高,特异性强“可用于临床药动学研究和治疗药物监测。八名小儿静滴头孢唑啉钠的药物动力学符合二室开放式模型。静滴后即刻峰浓度为217,10mg/L,消除半衰期为120小时,表观分布容积为0,31L/kg。
A HPLC method for the determination of cefazolin sodium intravenous drip in children during the period of pharmacokinetics using high performance liquid chromatography with trace amount of cefazolin. This Law from cephradine as an internal standard. C18 radial pressure column, 0,01 M sodium acetate / methanol (75/25) as the mobile phase, 254nm detection. The methodological evaluation indicated that this method is sensitive, accurate and specific.It can be used in clinical pharmacokinetic studies and therapeutic drug monitoring.The pharmacokinetics of cefazolin sodium in eight pediatric patients conformed to the two-compartment open model. Immediately after the peak concentration of 217,10 mg / L, elimination half-life of 120 hours, the apparent volume of distribution of 0,31 L / kg.