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分别用放射免疫法（ＲＩＡ）和二磷酸腺苷诱导法，测定了犬冠脉内灌注Ｎ－单甲基左旋精氨酸（Ｌ－ＮＭＭＡ）５ｍｇ／ｋｇ前后，前降支（ＬＡＤ）伴行静脉血中６－酮－前列腺素Ｆ１α（６－酮－ＰＧＦ１α）的含量和血小板聚集率（ＰＡｇＲ）。结果表明，Ｌ－ＮＭＭＡ灌注后血小板聚集率由３１．３％±６．６％升至４３．３％±６．２％（Ｐ＜０．０１），但６－酮－ＰＧＦ１α没有明显变化。以上结果提示内源性一氧化氮合成受抑制时，冠脉循环中ＰＡｇＲ增加，而前列腺素无变化。
Radioimmunoassay (RIA) and adenosine diphosphate (Adenosine diphosphate) induction were used to determine the effects of coronary artery perfusion with 5-mg / kg N-monomethyl-L-arginine (L-NMMA) The contents of 6-keto-PGF1α (6-keto-PGF1α) and platelet aggregation rate (PAgR) in venous blood. The results showed that platelet aggregation rate increased from 31.3% ± 6.6% to 43.3% ± 6.2% (P <0.01) after L-NMMA perfusion, but there was no significant change of 6-keto-PGF1α. The above results suggest that inhibition of endogenous nitric oxide synthesis increases PAgR in coronary circulation but not in prostaglandins.