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目的:对187例新生儿接种乙型肝炎疫苗3~4年后免疫效果进行观察分析,为今后的预防保健工作提供较有价值的参考信息。方法:选择2004年1月-2006年12月在重庆市红十字会医院妇产科出生的新生儿,在2007-2009年来医院预防保健科进行乙型肝炎疫苗强化免疫的儿童作为研究对象,要求是全程接种乙型肝炎疫苗3~4年后的儿童,经儿童家长同意,对儿童进行采血、登记以及资料的收集、整理、统计分析。结果:乙型肝炎表面抗体(HBs Ab)阳性共82例(43.85%);阴性105例(56.15%)。其中:男:89例,HBs Ab阳性共40例(44.94%);女:98例,HBs Ab阳性共42例(42.86%)。所观察187例儿童其他项目检测结果:乙型肝炎表面抗原(HBs Ag)阴性、乙型肝炎e抗原(HBe Ag)阴性、乙型肝炎e抗体(HBe Ab)阴性、乙型肝炎核心抗体(HBc Ab)阴性、肝功能检测指标均正常。结论:对新生儿每次采取5μg/0.5 m L,程序0,1,6进行全程乙型肝炎疫苗接种3~4年后其HBs Ab阳性率并不高,这是今后预防乙型肝炎工作的一个值得探讨和重视的问题。
OBJECTIVE: To observe and analyze the immunization effect of 187 newborns with hepatitis B vaccine for 3 to 4 years, and provide more valuable reference information for future preventive health care work. Methods: Newborns born in Obstetrics and Gynecology Department of Chongqing Red Cross Hospital from January 2004 to December 2006 were selected as the study subjects who received hepatitis B vaccine-boosted immunization from Hospital Preventive and Health Care Section from 2007 to 2009, Hepatitis B vaccine is vaccinated 3 to 4 years after the children, with the consent of the child’s parents, children’s blood collection, registration and data collection, sorting, statistical analysis. Results: There were 82 (43.85%) HBs Ab positive and 105 negative (56.15%) HBs Ab positive. Among them, 89 were male, 44 (44.94%) were positive for HBsAb, and 98 were female: 42 were positive for HBsAb (42.86%). The results of the other 187 children were tested: negative HBsAg, negative HBeAg, negative HBeAb, hepatitis B core antibody (HBcAg) Ab) negative, liver function tests were normal. CONCLUSIONS: The positive rate of HBs Ab in neonates after taking 5 μg / 0.5 m L of each program and 0,1,6 for whole-course hepatitis B vaccination for 3 to 4 years is not high, which is the future prevention of hepatitis B A question to be explored and valued.