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目的:探讨腹腔灌注抗生素对兔盆腔炎的疗效和意义。方法:以3×108cfu/kg的大肠埃希菌接种于30只雌兔双侧输卵管系膜并注射至双侧输卵管制成兔盆腔炎的动物模型。将形成盆腔炎的动物随机分成2组,腹腔穿刺灌注(腹腔组)15例,静脉给药(静脉组)15例,治疗后1月剖腹探查观察疗效。结果:腹腔组治愈率为80.0%,有效率为93.3%;静脉组治愈率为13.3%,有效率为66.7%。两组有效率比较差异有显著性(P<0.005)。结论:腹腔穿刺灌注抗生素用于治疗兔盆腔炎疗效优于静脉给药,且方法简单,副作用少,值得临床推广。
Objective: To investigate the efficacy and significance of intraperitoneal infusion of antibiotics on pelvic inflammatory disease in rabbits. Methods: Thirty rabbits were inoculated with 3 × 108 cfu / kg Escherichia coli into the bilateral tubal mesentery and injected into the bilateral fallopian tubes to make animal models of pelvic inflammatory disease. The animals with pelvic inflammatory disease were randomly divided into two groups: 15 cases underwent peritoneal perfusion (intraperitoneal group) and 15 cases underwent intravenous injection (vein group). The curative effect was observed by laparotomy in January after treatment. Results: The cure rate of the abdominal cavity group was 80.0% and the effective rate was 93.3%. The cure rate of the vein group was 13.3% and the effective rate was 66.7%. The difference between the two groups was significant (P <0.005). Conclusions: Peritoneal perfusion antibiotics is superior to intravenous injection in the treatment of pelvic inflammatory disease in rabbits. The method is simple and has few side effects and is worthy of clinical promotion.