急性心肌梗死合并心力衰竭采用基因重组人脑利钠肽治疗的临床观察

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目的探究在急性心肌梗死合并心力衰竭患者治疗中应用基因重组人脑利钠肽的应用效果。方法 80例急性心肌梗死合并心力衰竭患者,根据其挂号先后顺序进行分组,其中单号和双号分别设定为对照组和观察组,每组40例。对照组患者实施常规治疗,观察组患者应用基因重组人脑利钠肽进行治疗。对比两组患者的临床治疗效果以及患者治疗后的尿量、左室射血分数。结果观察组治疗总有效率为90.0%,高于对照组的62.5%,差异具有统计学意义(P<0.05)。治疗后观察组患者尿量(67.9±11.0)ml、左室射血分数(61.2±4.1)%,对照组尿量(52.8±9.1)ml、左室射血分数(39.4±3.5)%,观察组患者尿量、左室射血分数均优于对照组,差异均具有统计学意义(P<0.05)。结论急性心肌梗死合并心力衰竭患者在临床诊治过程中应用基因重组人脑利钠肽治疗对患者的病症有很好的改善,同时提升治疗效果,值得在临床治疗中推广应用。 Objective To explore the application of recombinant human brain natriuretic peptide in the treatment of patients with acute myocardial infarction complicated with heart failure. Methods Eighty patients with acute myocardial infarction complicated with heart failure were divided into groups according to the order of their registrations, in which the single number and the double number were set as the control group and the observation group with 40 cases in each group. Patients in the control group received routine treatment, and patients in the observation group were treated with recombinant human brain natriuretic peptide. The clinical efficacy of the two groups was compared with the urine output and the left ventricular ejection fraction after treatment. Results The total effective rate of observation group was 90.0%, higher than that of control group (62.5%), the difference was statistically significant (P <0.05). After treatment, the urine output of the observation group (67.9 ± 11.0) ml, the left ventricular ejection fraction (61.2 ± 4.1)%, the urine output of the control group (52.8 ± 9.1) ml and the left ventricular ejection fraction (39.4 ± 3.5)%, Urine volume and left ventricular ejection fraction of the patients in the group were better than those in the control group, with statistical significance (P <0.05). Conclusion The application of recombinant human brain natriuretic peptide in patients with acute myocardial infarction complicated with heart failure during the clinical diagnosis and treatment has a good improvement on the patient’s condition, and at the same time enhances the therapeutic effect, which is worth popularizing and applying in clinical treatment.
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