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目的探讨益生菌在重症急性胰腺炎(SAP)肝损害中的辅助治疗价值。方法27例重症急性胰腺炎肝损害患者均采用保守治疗,随机分为两组,治疗组(14例)在传统治疗基础上给予口服复合乳酸菌制剂(聚克),观察患者肝功能的变化情况,与对照组(13例)比较差异有统计学意义。结果与对照组相比,治疗组肝功能恢复时间及平均住院时间明显缩短(P均<0.05)。结论早期应用益生菌辅助治疗SAP肝损害,补充肠道正常菌群,减少细菌易位,可减轻急性胰腺炎时的肝损害,改善其病程及预后,降低病死率。
Objective To investigate the value of adjuvant therapy of probiotics in liver injury of severe acute pancreatitis (SAP). Methods Twenty-seven patients with severe acute pancreatitis and liver damage were treated conservatively and were randomly divided into two groups. The treatment group (14 cases) was given oral lactic acid bacteria (polyglutamic acid) orally on the basis of traditional treatment. The changes of liver function were observed, Compared with the control group (13 cases), the difference was statistically significant. Results Compared with the control group, the liver function recovery time and the average length of hospital stay in the treatment group were significantly shorter (all P <0.05). Conclusion Early application of probiotics in the treatment of SAP liver damage, normal intestinal flora and reduce bacterial translocation, can reduce acute liver injury in acute pancreatitis, improve its duration and prognosis, reduce mortality.